Associate Professor, Department of Applied Science, William & Mary, 2005-Present
Assistant Professor, Department of Applied Science, William & Mary, 2001-2005
Assistant Professor, Department of Mathematics, Arizona State University, 1999-2001
NRSA Fellow, Center for Neural Science, New York University, 1998-1999
IRTA Fellow, Mathematical Research Branch, NIDDK, NIH, 1996-1998

Ph.D. in Biophysics, University of California, Davis, 1996
B.S. in Biology, Massachusetts Institute of Technology, 1986

Thul R, Smith GD, Coombes S.    A bidomain fire-diffuse-fire model of propagating calcium waves.    J. Mathematical Biology   2007.   In press. (PDF)

Williams GSB, Huertas MA, Sobie EA, Jafri MS, and Smith GD.    A probability density approach to modeling local control of Ca-induced Ca release in cardiac myocytes.   Biophys. J. 92(7):2311--28, 2007.   (PDF)

Huertas MA and Smith GD.    The dynamics of luminal depletion and the stochastic gating of Ca activated Ca channels.   J. Theor. Biol. 246(2):332-54, 2007.   (PDF)

Huertas MA and Smith GD.    A multivariate population density model of the dLGN/PGN relay.   J. Comput. Neurosci. 21(2):171-89, 2006.   (PDF)

Means S, Smith AJ, Shepard J, Shadid J, Fowler J, Wojcikiewicz R, Mazel T, Smith GD, and Wilson BS.    Reaction diffusion modeling of calcium dynamics with realistic ER geometry.   Biophys. J. 91(2):537-57, 2006.   (PDF)

Huertas MA, Groff JR, and Smith GD.    Feedback inhibition and throughput properties of an integrate-and-fire-or-burst network model of retinogeniculate transmission.   J. Comput. Neurosci.   19(2):147-180, 2005.    (PDF)

DeRemigio H and Smith GD.    The dynamics of stochastic attrition viewed as an absorption time on a terminating Markov chain.   Cell Calcium. 38(2):73-86, 2005.    (PDF)

Mazzag B, Tignanelli C and Smith GD.    The effect of residual Ca²⁺ on the stochastic gating of Ca²⁺-regulated Ca²⁺ channel models.   J. Theor. Biol.   235:121-150, 2005.    (PDF)

Nguyen V, Mathias R, and Smith GD.    A stochastic automata network descriptor for Markov chain models of instantaneously-coupled intracellular Ca²⁺ channels.   Bull. Math. Bio.  67(3):393-432, 2005.    (PDF)

Smith GD and Sherman SM.    Detectability of excitatory vs. inhibitory drive in a stochastic thalamocortical relay neuron model.   J. Neurosci.   22(23)10242-10250, 2002.    (PDF)

Wilson SM, Mason HS, Smith GD, Nicholson N, Johnston L, Janiak R, and Hume JR.    Comparative capacitative Ca²⁺ entry mechanisms in canine pulmonary and renal arterial smooth muscle cells.  J. Physiol. (London).    543(Pt 3)917-31, 2002. (PDF)

Coombes S, Owen MR, and Smith GD.    Mode-locking in a periodically forced integrate-and-fire-or-burst neuron model.    Phys. Rev. E 64(041914):1-12, 2001. (PDF)

Smith GD, Cox CL, Sherman SM, and Rinzel J.   Spike-frequency adaptation in sinusoidally-driven thalamocortical relay neurons.   Thalamus and Related Systems. 1(2):135-156, 2001. (PDF)

Smith GD, Cox CL, Sherman SM, and Rinzel J. Fourier analysis of sinusoidally-driven thalamocortical relay neurons and a minimal integrate-and-fire-or-burst model.   J. Neurophys., 83(1):588-610, 2000.    (PDF)    (Associated .ode file)

Smith GD, Dai L, Miura R, and Sherman A.  Asymptotic analysis of buffered Ca²⁺ diffusion near a point source. SIAM J. Applied Math. 61(5):1816-1838, 2001.    (PDF)    (PostScript)    (Associated MATLAB scripts)

Bertram R, Smith GD, and Sherman A.  A modeling study of the effects of overlapping Ca²⁺ microdomains on neurotransmitter release.    Biophys. J., 76(2):735-50, 1999.    (PDF)

Keizer J, Smith GD, Ponce-Dawson S, and Pearson J.  Saltatory propagation of Ca²⁺ waves by Ca²⁺ sparks.   Biophys. J., 75(8):595-600, 1998.    (PDF)

Keizer J and Smith GD.  Spark-to-wave transition: saltatory transmission of Ca²⁺ waves in cardiac myocytes.    Biophys. Chem., 72:87-100, 1998.    (PDF)

Smith GD, Keizer J, Stern M, Lederer WJ, and Cheng H.  A simple numerical model of Ca²⁺ spark formation and detection in cardiac myocytes.  Biophys. J., 75(7):15-32, 1998.   (PDF)

Smith GD.  Analytical steady-state solution to the rapid buffering approximation near an open Ca²⁺ channel.  Biophys. J., 71(6):3064-3072, 1996.   (PDF)

Smith GD, Wagner J, and Keizer J. Validity of the rapid buffering approximation near a point source for Ca²⁺ ions.   Biophys. J. 70(6):2527-2539, 1996.   (PDF)

Smith GD, Lee RJ, Oliver JM, and Keizer J. The effect of Ca²⁺ influx on intracellular free Ca²⁺ responses in antigen-stimulated RBL-2H3 cells.   Am. J. Physiol. 270(3 Pt 1):C939-952, 1996.   (PDF)

Keizer J, Maki L, Greathouse J, Smith GD, and Bruinsma P.  Bistability and fluctuations for an incandescent light bulb.  J. Phys. Chem. 99(2):844-852, 1995.   (PDF)

Huertas MA and Smith GD.    A two-dimensional population density approach to modeling the dLGN/PGN network.   Neurocomputing, 2005.   In press.    (PDF)

Huertas MA, Groff JR, and Smith GD.    Feedback inhibition and throughput properties of an integrate-and-fire-or-burst network model of retinogeniculate transmission.   Neurocomputing.    65-66:499-505, 2005.    (PDF)

Smith GD.    Modeling intracellular calcium: diffusion, dynamics, and domains.   In: Modeling in the Neurosciences: From Biological Systems to Cognitive Robotics (Foundations of Analytical Neuroscience), 2nd Edition.    Reeke GN, Poznanski RR, Lindsay KA, Rosenberg JR, and Sporns O, eds., Pages 339-374. Taylor & Francis. 2005.

Smith GD.    An extended DeYoung-Keizer-like IP₃R model that accounts for domain Ca²⁺-mediated inactivation.    In: Recent Research Developments in Biophysical Chemistry, Vol. II. Condat CA and Baruzzi A, eds.   Pages 37-55. Research Signpost.   2002. (PDF)

Smith GD.  Modeling local and global Ca2+ signals using reaction-diffusion equations.  In Computational Neuroscience: Realistic Modeling for Experimentalists. De Schutter E, editor.   Pages 49-85. CRC Press. 2000.

Smith GD, Pearson J, and Keizer J.  Modeling intracellular Ca2+ waves and sparks.   (PDF)     In: Computational Cell Biology. Fall C, Marland E, Wagner J, Tyson J, editors.   Pages 198-229.  Springer-Verlag. 2002. Smith GD.  Modeling the stochastic gating of ion channels.  (PDF)     In: Computational Cell Biology. Fall C, Marland E, Wagner J, Tyson J, editors.   Pages 285-319.  Springer-Verlag. 2002.

Sherman A and Smith GD.  Relationship between deterministic rate constants and probability of binding.   Appendix in: Kennedy KM, Piper ST, Atwood HL. Synaptic vesicle recruitment for release explored by Monte Carlo simulation at the crayfish neuromuscular junction.   Can. J. Physiol. Pharmacol. 77(9):634-650, 1999.     (PDF)