Cellular Biophysics and Modeling
APSC 451/651, Fall 2005 syllabus
Classroom: McGlothlin-Street Hall #20
Meeting times: Tues/Thur 3:30 - 4:50 PM
Instructor
Christopher A. Del Negro, Ph.D.
Office: McGlothlin-Street Hall #303
Lab: McGlothlin-Street Hall #318
Phone: 757-221-7808
e-mail: cadeln@wm.edu
Software
XPPAUT, a program for simulating and analyzing differential equations, which will be used extensively throughout the class, and runs on Mac OS X, Linux, and Windows. The XPPAUT online tutorial can help you get started.
Note Windows users: In order to print postscript files, you may need to install GhostScript and GSView.
| Day | Date | Lecture | Topic |
| R | 8/25/05 | Lecture 1 | A mathematics for physiology |
| T | 8/30/05 | Lecture 2 | Geometric analysis, 1D flows |
| R | 9/1/05 | Lecture 3 | Linear stability analysis |
| T | 9/6/05 | Lecture 4 | Bifurcations in 1D, RC circuits |
| R | 9/8/05 | Lecture 5 | Nernst eq. and chord conductance |
| T | 9/13/05 | Lecture 6 | Parallel ohmic conductances |
| R | 9/15/05 | Lecture 7 | A bistable cell model |
| T | 9/20/05 | Lecture 8 | Nernst-Planck and Goldman theory |
| R | 9/22/05 | Lecture 9 | The bistable cell - revisited |
| T | 9/27/05 | Lecture 10 | Voltage-clamp and current isolation |
| R | 9/29/05 | Lecture 11 | Hodgkin-Huxley theory 1 |
| T | 10/4/05 | Lecture 12 | Hodgkin-Huxley theory 2 |
| R | 10/6/05 | key | Mid-term exam |
| T | 10/11/05 | Fall break - no class | |
| R | 10/13/05 | Lecture 13 | Linear ODEs in 2D |
| T | 10/18/05 | Lecture 14 | Classification of fixed points |
| R | 10/20/05 | Lecture 15 | The Morris-Lecar Model |
| T | 10/25/05 | Lecture 16 | Emergence of oscillations |
| R | 10/27/05 | Lecture 17 | Oscillations and Hopf bifurcations |
| T | 11/1/05 | Lecture 18 | Oscillations at zero frequency |
| R | 11/3/05 | Fall Neuroscience Symposium | |
| T | 11/8/05 | Lecture 19 | |
| R | 11/10/05 | Special: spinal cord networks | |
| T | 11/15/05 | SFN - no class | |
| R | 11/17/05 | Experimental Data Analysis HW | |
| T | 11/22/05 | Lecture 20 | |
| R | 11/24/05 | Thanksgiving - no class | |
| T | 11/29/05 | Lecture 21 | Integrate-and-fire models |
| R | 12/1/05 | Lecture 22 | Generating bifurcation diagrams |